This Is Why We Sigh

Tiredness, sadness, and relief all feel very different, and yet sighing somehow seems to complement each emotional state. But why do we do it? There have been lots of theories, but no one is quite sure. Now researchers have filled in an important piece of the puzzle: They have discovered the neurological pathways responsible for the frequency of sighing, independent of regular breathing. The study was published today in Nature.

A sigh, defined here as a deep long breath about twice the volume of a typical breath, is of course involved with your emotions. It also serves as a sort of stretch for your lungs—a periodic deep breath inflates the alveoli, tiny sacs in the lungs where oxygen and carbon dioxide pass in and out of the blood.

If clinicians could the levels of these compounds, they could increase sighing in patients who have trouble breathing on their own

That stretch is critical to keep lungs working properly. “When alveoli collapse, they compromise the ability of the lung to exchange oxygen and carbon dioxide,” Jack Feldman, a neurobiologist at UCLA and one of the study authors said in a press release. “The only way to pop them open again is to sigh, which brings in twice the volume of a normal breath. If you don’t sigh, your lungs will fail over time.”

That’s likely why the brain triggers a sigh about a dozen times per hour in humans, and more frequently in animals. But scientists had never been able to identify the neurons in the brain that activated this reflex.

The researchers decided to look in the brain’s breathing center in the brainstem. They analyzed the genes in those cells and found that a few hundred of them generate one of two chemicals that allow them to communicate with the “preBötzinger Complex,” a bundle of a few thousand neurons known to control the rate and rhythm of respiration.

When the researchers injected these previously isolated compounds, known as “Nmb” or “Grp”, into the mice’s brains, they found that the mice sighed 10 times more often per hour. When the researchers blocked the Nmb peptide, the mice sighed only half as often as they had originally; inhibiting the pathways made the mice almost stop sighing altogether. None of these changes affected the mice’s normal breathing.

That’s likely why the brain triggers a sigh about a dozen times per hour in humans, and more frequently in animals. But scientists had never been able to identify the neurons in the brain that activated this reflex.

The researchers decided to look in the brain’s breathing center in the brainstem. They analyzed the genes in those cells and found that a few hundred of them generate one of two chemicals that allow them to communicate with the “preBötzinger Complex,” a bundle of a few thousand neurons known to control the rate and rhythm of respiration.

When the researchers injected these previously isolated compounds, known as “Nmb” or “Grp”, into the mice’s brains, they found that the mice sighed 10 times more often per hour. When the researchers blocked the Nmb peptide, the mice sighed only half as often as they had originally; inhibiting the pathways made the mice almost stop sighing altogether. None of these changes affected the mice’s normal breathing.

Written by By Alexandra Ossola | Popular Science 


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